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Pfaar, H. ; von Holst, A.* ; Vogt Weisenhorn, D.M.* ; Brodski, C.* ; Guimera, J.* ; Wurst, W.

mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons.

Dev. Genes Evol. 212, 43-46 (2002)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Here we describe the expression pattern of a previously unknown mouse gene mPet-1. The isolated cDNA codes for an ETS-domain transcription factor of 237 amino acids in length, which is localized to the nucleus. mPet-1 is a member of the winged helix transcription factor gene family like its rat homologue Pet-1 and the human homologue FEV. The start ATG of mPet-1 and the size of the predicted protein are identical to the human FEV. The mPet-1 protein is clearly smaller since it lacks the first 103 N-terminal amino acids of rat Pet-1. mPet-1 is expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood. In these regions mPet-1 expression co-localizes precisely with the serotonin transporter (Sert), which it initially precedes. Interestingly, mPet-1 was not found in neurons transiently expressing Sert.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Pet-1; Raphe nuclei; Brain; Serotonin; Development
ISSN (print) / ISBN 0949-944X
e-ISSN 1432-041X
Quellenangaben Band: 212, Heft: 1, Seiten: 43-46 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed