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Peter, C.* ; Waibel, M.* ; Keppeler, H.* ; Lehmann, R.* ; Xu, G.* ; Halama, A. ; Adamski, J. ; Schulze-Osthoff, K.* ; Wesselborg, S.* ; Lauber, K.*

Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.

Autoimmunity 45, 568-573 (2012)
Open Access Green as soon as Postprint is submitted to ZB.
Efficient engulfment of apoptotic cells is essential in multi-cellular organisms in order to prevent inflammatory responses. Apoptotic cells secure this process by releasing 'find-me' signals for the attraction of phagocytes. A major 'find-me' signal liberated from apoptotic cells is lysophosphatidylcholine (LPC). So far, however, the mechanisms underlying LPC release are poorly understood. In this study, we demonstrate that pharmacological inhibition and RNAi-mediated knock-down of the lipid transporter ABCA1 in apoptotic cells completely abolished phagocyte attraction. Moreover, ectopic expression of ABCA1 significantly enhanced monocyte migration to supernatants of apoptotic cells. Hence, ABCA1 represents a novel regulator of LPC release during apoptosis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Apoptosis; chemotaxis; 'find-me' signal; lysophosphatidylcholine; ATP-binding cassette transporter; TANGIER-DISEASE; CELL-DEATH; ENGULFMENT; CLEARANCE; PHAGOCYTOSIS; MIGRATION; ELEGANS; ABC1; ACT
ISSN (print) / ISBN 0891-6934
e-ISSN 1607-842X
Journal Autoimmunity
Quellenangaben Volume: 45, Issue: 8, Pages: 568-573 Article Number: , Supplement: ,
Publisher Informa Healthcare
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)