PuSH - Publication Server of Helmholtz Zentrum München

Blind source separation using latent gaussian graphical models.

In: Proceedings (Ninth International Workshop on Computational Systems Biology, WCSB 2012, June 4-6, 2012, Ulm, Germany). Tampere, Finnland: Tampere International Center for Signal Processing, 2012. 43-46 (Proc. WCSB ; 61)
Order publishers version
Dealing with data of a specific temporal or spatial structure is well established in blind source separation. However, in biology one often faces more complex network structures. The recently published GraDe-algorithm addresses such structures; it separates sources with respect to a given network in an analytical manner. We formulate corresponding assumptions and assign them to a very flexible Bayesian model. This allows us to include for instance missing observations and use prior parameter knowledge. Technically, we propose a Gaussian graphical model with latent variables to include all structural information from the data. The parameters and latent variables are estimated using expectation maximization, where we exploit the restrictions given by the separation assumptions. In a large scale application we consider gene expression data, where the dependence structure is given by a gene regulatory network. We demonstrate how the model indeed identifies relevant biological processes.
Additional Metrics?
Icb_biostatistics Icb_Latent Causes Icb_ML
Edit extra informations Login
Publication type Article: Conference contribution
Conference Title Ninth International Workshop on Computational Systems Biology, WCSB 2012, June 4-6, 2012, Ulm, Germany
Proceedings Title Proceedings
Quellenangaben Volume: 61, Issue: , Pages: 43-46 Article Number: , Supplement: ,
Series TICSP series
Publisher Tampere International Center for Signal Processing
Publishing Place Tampere, Finnland