Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Previous lung diseases and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium.
Am. J. Epidemiol. 176, 573-585 (2012)
To clarify the role of previous lung diseases (chronic bronchitis, emphysema, pneumonia, and tuberculosis) in the development of lung cancer, the authors conducted a pooled analysis of studies in the International Lung Cancer Consortium. Seventeen studies including 24,607 cases and 81,829 controls (noncases), mainly conducted in Europe and North America, were included (19842011). Using self-reported data on previous diagnoses of lung diseases, the authors derived study-specific effect estimates by means of logistic regression models or Cox proportional hazards models adjusted for age, sex, and cumulative tobacco smoking. Estimates were pooled using random-effects models. Analyses stratified by smoking status and histology were also conducted. A history of emphysema conferred a 2.44-fold increased risk of lung cancer (95 confidence interval (CI): 1.64, 3.62 (16 studies)). A history of chronic bronchitis conferred a relative risk of 1.47 (95 CI: 1.29, 1.68 (13 studies)). Tuberculosis (relative risk 1.48, 95 CI: 1.17, 1.87 (16 studies)) and pneumonia (relative risk 1.57, 95 CI: 1.22, 2.01 (12 studies)) were also associated with lung cancer risk. Among never smokers, elevated risks were observed for emphysema, pneumonia, and tuberculosis. These results suggest that previous lung diseases influence lung cancer risk independently of tobacco use and that these diseases are important for assessing individual risk.
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Schlagwörter Bronchitis ; Chronic ; Emphysema ; Lung Diseases ; Lung Neoplasms ; Meta-analysis ; Pneumonia ; Pulmonary Disease ; Chronic Obstructive ; Tuberculosis; OBSTRUCTIVE PULMONARY-DISEASE; ENVIRONMENTAL TOBACCO-SMOKE; RESIDENTIAL RADON; PREDICTION MODEL; SCREENING TRIAL; NEVER-SMOKERS; INFLAMMATION; ASSOCIATION; VALIDATION; VARIANTS
ISSN (print) / ISBN 0002-9262
Zeitschrift American Journal of Epidemiology
Quellenangaben Band: 176, Heft: 7, Seiten: 573-585
Verlag Oxford University Press
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)