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Delogu, A.* ; Sellers, K.* ; Zagoraiou, L.* ; Bocianowska-Zbrog, A.* ; Mandal, S.* ; Guimera, J. ; Rubenstein, J.L.R.* ; Sugden, D.* ; Jessell, T.* ; Lumsden, A.*

Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms.

Neuron 75, 648-662 (2012)
Verlagsversion Volltext DOI
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Intrinsically photosensitive retinal ganglion cells (ipRGCs) and their nuclear targets in the subcortical visual shell (SVS) are components of the non-image-forming visual system, which regulates important physiological processes, including photoentrainment of the circadian rhythm. While ipRGCs have been the subject of much recent research, less is known about their central targets and how they develop to support specific behavioral functions. We describe Sox14 as a marker to follow the ontogeny of the SVS and find that the complex forms from two narrow stripes of Dlx2-negative GABAergic progenitors in the early diencephalon through sequential waves of tangential migration. We characterize the requirement for Sox14 to orchestrate the correct distribution of neurons among the different nuclei of the network and describe how Sox14 expression is required both to ensure robustness in circadian entrainment and for masking of motor activity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Olivary Pretectal Nucleus ; Retinal Ganglion-cells ; Geniculo-hypothalamic Tract ; Hamster Circadian-rhythms ; Pupillary Light Reflex ; Intergeniculate Leaflet ; Suprachiasmatic Nucleus ; Neuropeptide-y ; Sonic Hedgehog ; Locomotor-activity
ISSN (print) / ISBN 0896-6273
e-ISSN 1097-4199
Zeitschrift Neuron
Quellenangaben Band: 75, Heft: 4, Seiten: 648-662 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed