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Towards better mouse models: Enhanced genotypes, systemic phenotyping and envirotype modelling.
Nat. Rev. Genet. 10, 371-380 (2009)
The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions-the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.
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Publication type Article: Journal article
Document type Review
Keywords zinc-finger nucleases; mice lacking vimentin; chromosome substitution strains; copy-number variation; enu mutagenesis; collaborative cross; rna interference; phenome project; complex traits; gene-function
ISSN (print) / ISBN 1471-0056
Journal Nature Reviews - Genetics
Quellenangaben Volume: 10, Issue: 6, Pages: 371-380
Publisher Nature Publishing Group
Reviewing status Peer reviewed