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Rzehak, P. ; Heinrich, J. ; Klopp, N. ; Schaeffer, L. ; Hoff, S.* ; Wolfram, G.* ; Illig, T. ; Linseisen, J.

Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes.

Br. J. Nutr. 101, 20-26 (2009)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The present study gives further evidence for the recently found association between variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and PUFA in blood phospholipids and explores this association for cellular fatty acids in erythrocyte membranes. In a subgroup of adults participating in the Bavarian Nutrition Survey 11, a cross-sectional population-based study conducted in Bavaria, Germany, allelic variation in three selected loci of the FADS1 FADS2 gene cluster was analysed and used for haplotype construction. Associations with plasma phospholipid PUFA (it 163) and PUFA in erythrocyte membranes (n 535) were investigated by regression analysis. All haplotypes of the original five-loci haplotypes of our previous study could be replicated. In addition, associations with serum phospholipid PUFA were confirmed in the present data set. Although less pronounced, associations between FADS1 FADS2 haplotypes and PUFA in erythrocyte membranes, particularly arachidonic and dihomo-gamma-linolenic acid, could be established. We provide the first replication of the association of the FADS1 FADS2 gene cluster with PUFA in blood phospholipids. For the first time, such associations were also shown for PUFA in cell membranes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter FADS1 FADS2 gene cluster; Polyunsaturated fatty acids; Blood phospholipids; Erythrocyte membranes; Bavarian Nutrition Survey II; alpha-linolenic acid; linkage disequilibrium; lipids; diet; inflammation; eicosanoids; desaturase; expression; haplotypes; rhinitis
ISSN (print) / ISBN 0007-1145
e-ISSN 1475-2662
Quellenangaben Band: 101, Heft: 1, Seiten: 20-26 Artikelnummer: , Supplement: ,
Verlag Cambridge Univ. Press
Begutachtungsstatus Peer reviewed