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Improving limited-projection-angle fluorescence molecular tomography using a co-registered X-ray computed tomography scan.

J. Biomed. Opt. 17:126011 (2012)
Publ. Version/Full Text Volltext DOI
Open Access Green as soon as Postprint is submitted to ZB.
We examine the improvement in imaging performance, such as axial resolution and signal localization, when employing limited-projection-angle fluorescence molecular tomography (FMT) together with x-ray computed tomography (XCT) measurements versus stand-alone FMT. For this purpose, we employed living mice, bearing a spontaneous lung tumor model, and imaged them with FMT and XCT under identical geometrical conditions using fluorescent probes for cancer targeting. The XCT data was employed, herein, as structural prior information to guide the FMT reconstruction. Gold standard images were provided by fluorescence images of mouse cryoslices, providing the ground truth in fluorescence bio-distribution. Upon comparison of FMT images versus images reconstructed using hybrid FMT and XCT data, we demonstrate marked improvements in image accuracy. This work relates to currently disseminated FMT systems, using limited projection scans, and can be employed to enhance their performance.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Fluorescence Molecular Tomography ; X-ray Computed Tomography ; Co-registration ; Multimodality ; Molecular Imaging ; Hybrid Imaging ; Priors ; Reconstruction; Diffuse Optical Tomography ; Normalized Born Approximation ; In-vivo ; Magnetic-resonance ; Structural Information ; Imaging-system ; Breast ; Cancer ; Mri ; Mice
ISSN (print) / ISBN 1083-3668
e-ISSN 1560-2281
Quellenangaben Volume: 17, Issue: 12, Pages: , Article Number: 126011 Supplement: ,
Publisher SPIE
Reviewing status Peer reviewed