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de Hartog, J.J.* ; Lanki, T.* ; Timonen, K.L.* ; Hoek, G.* ; Janssen, N.A.H.* ; Ibald-Mulli, A. ; Peters, A. ; Heinrich, J. ; Tarkiainen, T.H.* ; van Grieken, R.* ; van Wijnen, J.H.* ; Brunekreef, B.* ; Pekkanen, J.*

Associations between PM2.5 and heart rate variability are modified by particle composition and beta-blocker use in patients with coronary heart disease.

Environ. Health Perspect. 117, 105-111 (2009)
Verlagsversion Volltext DOI
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BACKGROUND: It has been hypothesized that ambient particulate air pollution is able to modify the autonomic nervous control of the heart, measured as heart rate variability (HRV). Previously we reported heterogeneous associations between particulate matter with aerodynamic diameter < 2.5 mu m (PM2.5) and HRV across three study centers. OBJECTIVE: We evaluated whether exposure misclassification, effect modification by medication, or differences in particle composition could explain die inconsistencies. METHODS: Subjects with coronary heart disease visited clinics biweekly in Amsterdam, the Netherlands; Erfurt, Germany; and Helsinki, Finland for 6-8 months. The standard deviation (SD) of NN intervals on an electrocardiogram (ECG; SDNN) and high frequency (HF) power of HRV was measured with ambulatory ECG during paced breathing. Outdoor levels of PM2.5 were measured at a central site. In Amsterdam and Helsinki, indoor and personal PM2.5 were measured during the 24 hr preceding the clinic visit. PM2.5 was apportioned between sources using principal component analyses. We analyzed associations of indoor/personal PM2.5 elements of PM2.5 and source-specific PM2.5 With HRV using linear regression. RESULTS: Indoor and personal PM2.5 were not associated with HRV. Increased outdoor PM2.5 was associated with decreased SDNN and HF at lags of 2 and 3 days only among persons not using beta-blocker medication. Traffic-related PM2.5 was associated with decreased SDNN, and long-range transported PM2.5 with decreased SDNN and HF, most strongly among persons not using beta blockers. Indicators for PM2.5 from traffic and long-range transport were also associated with decreased HRV. CONCLUSIONS: Our results suggest that differences in the composition of particles, beta-blocker use, and obesity of study subjects may explain some inconsistencies among previous studies on HRV.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter absorbance; air pollution; cardiovascular health; elements of PM2.5; heart rate variability; medication; PM2.5; source-specific particulate matter; fine particulate matter; cardiac autonomic control; ambient air-pollution; 3 european cities; artery-disease; myocardial-infarction; elderly subjects; mortality; exposure; population; FINE PARTICULATE MATTER; CARDIAC AUTONOMIC CONTROL; AMBIENT AIR-POLLUTION; 3 EUROPEAN CITIES; ARTERY-DISEASE; MYOCARDIAL-INFARCTION; ELDERLY SUBJECTS; MORTALITY; EXPOSURE; POPULATION
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Quellenangaben Band: 117, Heft: 1, Seiten: 105-111 Artikelnummer: , Supplement: ,
Verlag Research Triangle Park
Verlagsort NC [u.a.]
Begutachtungsstatus Peer reviewed