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Castro-Giner, F.* ; Künzli, N.* ; Jacquemin, B.* ; Forsberg, B.* ; de Cid, R.* ; Sunyer, J.* ; Jarvis, D.* ; Briggs, D.* ; Vienneau, D.* ; Norbäck, D.* ; Gonzalez, J.R.* ; Guerra, S.* ; Janson, C.* ; Antò, J.M.* ; Wjst, M. ; Heinrich, J. ; Estivill, X.* ; Kogevinas, M.*

Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).

Environ. Health Perspect. 117, 1919-1924 (2009)
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BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor alpha (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor beta2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.
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Publication type Article: Journal article
Document type Scientific Article
Keywords air pollution; asthma; gene polymorphisms; genetics; nitrogen dioxide; oxidative stress; traffic pollution; COMMUNITY-RESPIRATORY-HEALTH; TUMOR-NECROSIS-FACTOR; S-TRANSFERASE P1; CHILDHOOD ASTHMA; LUNG-FUNCTION; ENVIRONMENT INTERACTIONS; ALLERGIC RESPONSES; BIRTH COHORT; RISK-FACTORS; ASSOCIATION
ISSN (print) / ISBN 0091-6765
e-ISSN 1552-9924
Quellenangaben Volume: 117, Issue: 12, Pages: 1919-1924 Article Number: , Supplement: ,
Publisher Research Triangle Park
Publishing Place NC [u.a.]
Reviewing status Peer reviewed