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Rogowski, W.H. ; Grosse, S.D.* ; Khoury, M.J.*

Challenges of translating genetic tests into clinical and public health practice.

Nat. Rev. Genet. 10, 489-495 (2009)
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Research in genetics and genomics has led to an expanding list of molecular genetic tests, which are increasingly entering health care systems. However, the evidence surrounding the benefits and harms of these tests is frequently weak. Here we present the main challenges to the successful translation of new research findings about genotype-phenotype associations into clinical practice. We discuss the means to achieve an accelerated translation research agenda that is conducted in a reasonable, fair and efficient manner.
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Publication type Article: Journal article
Document type Review
Keywords egapp working group; cost-effectiveness; technology-assessment; reducing morbidity; colorectal-cancer; lynch syndrome; services; care; strategies; disorders
ISSN (print) / ISBN 1471-0056
e-ISSN 1471-0064
Quellenangaben Volume: 10, Issue: 7, Pages: 489-495 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed