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Maekawa, M.* ; Okamura, T.* ; Kasai, N.* ; Hori, Y.* ; Summer, K.H. ; Konno, R.*

D-Amino-acid Oxidase Is Involved in D-Serine-Induced Nephrotoxicity.

Chem. Res. Toxicol. 18, 1678-1682 (2005)
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d-Serine is nephrotoxic in rats. Based on circumstantial evidence, it has been suspected that d-amino-acid oxidase is involved in this nephrotoxicity. Since we found that LEA/SENDAI rats lacked d-amino-acid oxidase, we examined whether this enzyme was associated with d-serine-induced nephrotoxicity using the LEA/SENDAI rats and control F344 rats. When d-propargylglycine, which is known to have a nephrotoxic effect through its metabolism by d-amino-acid oxidase, was injected intraperitoneally into the F344 rats, it caused glucosuria and polyuria. However, injection of d-propargylglycine into LEA/SENDAI rats did not cause any glucosuria or polyuria, indicating that d-amino-acid oxidase is definitely not functional in these rats. d-Serine was then injected into the F344 and LEA/SENDAI rats. It caused glucosuria and polyuria in the F344 rats but not in the LEA/SENDAI rats. These results indicate clearly that d-amino-acid oxidase is responsible for the d-serine-induced nephrotoxicity.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0893-228X
e-ISSN 1520-5010
Quellenangaben Volume: 18, Issue: 11, Pages: 1678-1682 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Reviewing status Peer reviewed