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Ganesh, S.K.* ; Zakai, N.A.* ; van Rooij, F.J.A.* ; Soranzo, N.* ; Smith, A.V.* ; Nalls, M.A.* ; Chen, M.H.* ; Köttgen, A.* ; Glazer, N.L.* ; Dehghan, A.* ; Kühnel, B. ; Aspelund, T.* ; Yang, Q.* ; Tanaka, T.* ; Jaffe, A.* ; Bis, J.C.M.* ; Verwoert, G.C.* ; Teumer, A.* ; Fox, C.S.* ; Guralnik, J.M.* ; Ehret, G.B.* ; Rice, K.* ; Felix, J.F.* ; Rendon, A.* ; Eiriksdottir, G.* ; Levy, D.* ; Patel, K.V.* ; Boerwinkle, E.* ; Rotter, J.I.* ; Hofman, A.* ; Sambrook, J.G.* ; Hernandez, D.G.* ; Zheng, G.* ; Bandinelli, S.* ; Singleton, A.B.* ; Coresh, J.* ; Lumley, T.* ; Uitterlinden, A.G.* ; vanGils, J.M.* ; Launer, L.J.* ; Cupples, L.A.* ; Oostra, B.A.* ; Zwaginga, J.J.* ; Ouwehand, W.H.* ; Thein, S.L.* ; Meisinger, C. ; Deloukas, P.* ; Nauck, M.* ; Spector, T.D.* ; Gieger, C. ; Gudnason, V.* ; van Duijn, C.M.* ; Psaty, B.M.* ; Ferrucci, L.* ; Chakravarti, A.* ; Greinacher, A.* ; O'Donnell, C.J.* ; Witteman, J.C.M.* ; Furth, S.* ; Cushman, M.* ; Harris, T.B.* ; Lin, J.P.*

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

Nat. Genet. 41, 1191-1198 (2009)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Measurements of erythrocytes within the blood are important clinical traits and can indicate various hematological disorders. We report here genome-wide association studies (GWAS) for six erythrocyte traits, including hemoglobin concentration (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red blood cell count (RBC). We performed an initial GWAS in cohorts of the CHARGE Consortium totaling 24,167 individuals of European ancestry and replication in additional independent cohorts of the HaemGen Consortium totaling 9,456 individuals. We identified 23 loci significantly associated with these traits in a meta-analysis of the discovery and replication cohorts (combined P values ranging from 5 x 10(-8) to 7 x 10(-86)). Our findings include loci previously associated with these traits (HBS1L-MYB, HFE, TMPRSS6, TFR2, SPTA1) as well as new associations (EPO, TFRC, SH2B3 and 15 other loci). This study has identified new determinants of erythrocyte traits, offering insight into common variants underlying variation in erythrocyte measures.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter genome-wide association; blood-pressure; hemoglobin concentration; hemochromatosis gene; hereditary hemochromatosis; cardiovascular-disease; myocardial-infarction; fetal-hemoglobin; celiac-disease; c-myb
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 41, Heft: 11, Seiten: 1191-1198 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed