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Rzehak, P. ; Sausenthaler, S. ; Koletzko, S.* ; Reinhardt, D.* ; von Berg, A.* ; Krämer, U.* ; Berdel, D.* ; Bollrath, C.* ; Grubl, A.* ; Bauer, C.P.* ; Wichmann, H.-E. ; Heinrich, J.

Short- and long-term effects of feeding hydrolyzed protein infant formulas on growth at ≤ 6 y of age: Results from the German Infant Nutritional Intervention Study.

Am. J. Clin. Nutr. 89, 1846-1856 (2009)
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The short- and long-term effects of feeding with hydrolyzed formulas on growth are uncertain. Objective: Our aim was to investigate the potential differences in body mass index (BMI) over the first 6 y of life between infants fed with partially hydrolyzed whey (pHF-W), extensively hydrolyzed whey (eHF-W), extensively hydrolyzed casein (eHF-C), or cow-milk formula (CMF) and infants exclusively breastfed for the first 16 wk of life. Design: We established a prospective, randomized, double-blind trial of full-term neonates with atopic heredity in the German birth cohort followed by the German Infant Nutritional Intervention Study through the first 6 y of life. Intention-to-treat and per-protocol analyses of absolute and World Health Organization-standardized BMI trajectories for 1840 infants (pHF-W: n = 253; eHF-W: n 265; eHF-C: n = 250, CMF: n = 276; breastfed: n = 796) were performed. Results: No significant differences in absolute or World Health Organization-standardized BMI trajectories were found among the pHF-W, eHF-W, CMF, and breastfed groups during the 6-y follow-up. However, in the eHF-C group, both intention-to-treat and per-protocol analyses showed a significantly slower sex-adjusted BMI gain through the 8th to 48th week of life (-0.1 to -0.2 lower BMI z score) but not beyond. Analyses of weight and length revealed that this difference is due to a slightly diminished weight gain in the first year of life because growth in length did not differ among study groups for the entire follow-up. Conclusions: To our knowledge, this is the first randomized trial investigating both short-and long-term effects of partially and extensively hydrolyzed formula (pHF-W, eHF-W, eHF-C), CMF, and breastfeeding on growth in one trial. Feeding with eHF-C led to a transient lower weight gain in the first year of life. No long-term consequences of different formulas on BMI were observed.
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Publication type Article: Journal article
Document type Scientific Article
Keywords cows milk allergy; atopic-dermatitis; amino-acids; standards; life; children; trial
ISSN (print) / ISBN 0002-9165
e-ISSN 1938-3207
Quellenangaben Volume: 89, Issue: 6, Pages: 1846-1856 Article Number: , Supplement: ,
Publisher American Society for Nutrition
Reviewing status Peer reviewed