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Welteke, V. ; Eitelhuber, A.C. ; Düwel, M. ; Schweitzer, K.* ; Naumann, M.* ; Krappmann, D.

COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation.

EMBO Rep. 10, 642-648 (2009)
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The Carma1-Bcl10-Malt1 (CBM) complex connects T-cell receptor (TCR) signalling to the canonical I kappa B kinase (IKK)/NF (nuclear factor)-kappa B pathway. Earlier studies have indicated that the COP9 signalosome (CSN), a pleiotropic regulator of the ubiquitin/26S proteasome system, controls antigen responses in T cells. The CSN is required for the degradation of the NF-kappa B inhibitor I kappa B alpha, but other molecular targets involved in T-cell signalling remained elusive. Here, we identify the CSN subunit 5 (CSN5) as a new interactor of Malt1 and Carma1. T-cell activation triggers the recruitment of the CSN to the CBM complex, and CSN downregulation impairs TCR-induced IKK activation. Furthermore, the CSN is required for maintaining the stability of Bcl10 in response to T-cell activation. Taken together, our data provide evidence for a functional link between the evolutionarily conserved CSN and the adaptive immunoregulatory CBM complex in T cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter COP9 signalosome; signalling; T-cell activation; nf-kappa-b; ubiquitin ligases; activation; bcl10; cycle; regulator; csn; phosphorylation; degradation; subcomplex
ISSN (print) / ISBN 1469-221X
e-ISSN 1469-3178
Zeitschrift EMBO Reports
Quellenangaben Band: 10, Heft: 6, Seiten: 642-648 Artikelnummer: , Supplement: ,
Verlag EMBO Press