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Mutagenicity Testing of Vincristine Sulfate in Germ Cells of Male Mice.

Mutat. Res. Let. 209, 107-113 (1988)
Verlagsversion DOI
Vincristine sulfate (VCR) affects the fertilization ability of all germ-cell stages in male mice. The reduced fertilization ability leads to a pseudo-dominant-lethal effect and sterile matings. The frequency of these effects is dose-dependent. The frequency of specific-locus mutations was not increased by VCR in male mice following 2 mg/kg bw treatment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Specific-locus mutations; Dominant-lethal mutations; Male mice; Pseudo-dominant-lethal effect; Vincristine sulfate
ISSN (print) / ISBN 0165-7992
e-ISSN 1878-7053
Quellenangaben Band: 209, Heft: 3-4, Seiten: 107-113 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed