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Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: Results from the MONICA/KORA Augsburg cohort study.
Eur. Heart J. 26, 271-278 (2005)
Aims To investigate the association between apolipoprotein B (apoB), A-I (apoA-I), the apoB/apoA-I ratio, and the incidence of coronary events. Methods and results Analysis included 1414 men and 1436 women aged 35–64 years without a prior coronary event who participated in the population-based MONICA Augsburg survey 1984–85 (median followed-up period 13 years). Incidence of fatal and non-fatal myocardial infarction, and sudden cardiac death was assessed using data of the MONICA/KORA Augsburg coronary event registry. During follow-up, 114 incident coronary events occurred in men and 31 in women. In multivariable analysis, an increase of 1 standard deviation in the serum concentration of apoB was associated with an increased risk of coronary events in men [hazard ratio (HR)=1.49; 95% confidence interval (CI); 1.25–1.78] and in women (HR=1.73; 95% CI; 1.32–2.27). By contrast, elevated concentrations of apoA-I were not associated with a significantly decreased risk of coronary events in either sex (HR=0.91). Furthermore, the predictive power of the apoB/apoA-I ratio was similar to that of the total cholesterol/HDL cholesterol ratio in men and women. Conclusion ApoB and the apoB/apoA-I ratio were strong predictors of coronary events in middle-aged men and women, whereas apoA-I did not add significantly to the estimation of future coronary risk.
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Publication type Article: Journal article
Document type Scientific Article
Keywords cohort study; apolipoprotein B; apolipoprotein A-I; coronary event; prognostic value
ISSN (print) / ISBN 0195-668X
Journal European Heart Journal
Quellenangaben Volume: 26, Pages: 271-278
Publisher Oxford University Press
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)