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Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.
Biochim. Biophys. Acta-Gen. Subj. 1790, 1575-1585 (2009)
Selenium, as an integral part of selenoproteins, is essential for mammals. Unequivocal evidence had been provided more than a decade ago when it was proven that mice incapable of producing any of the 24 selenoproteins failed to develop beyond the gastrulation stage (E6.5). Since then, more specific attempts have been made to unmask novel and essential functions of individual selenoproteins in mice. Genetic disruption of glutathione peroxidase 4 (GPx4; also referred to as phospholipid hydroperoxide glutathione peroxidase, PHGPx) in mice showed for the first time that a specific selenoenzyme is in fact required for early embryonic development. Later on, systemic ablation of cytosolic thioredoxin reductase (Txnrd1) or mitochondrial thioredoxin reductase (Txnrd2) yielded embryonic lethal phenotypes. Beside those three, no other selenoproteins have been found being indispensable for murine development so far. This review aims at summarizing mainly the in vivo findings on these important mammalian selenoenzymes, which have not only common attributes of being required for embryogenesis, but that they are also instrumental in the regulation of cellular redox metabolism.
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Publication type Article: Journal article
Document type Review
Keywords Apoptosis inducing factor (aif); cre/loxp; 12/15-lipoxygenase; Oxidative stress; phgpx; Redox regulation; Early embryonic lethality; Apoptosis-inducing factor; Carcinoma a431 cells; Transfer-rna gene; Mammalian thioredoxin; Oxidative stress; Targeted disr
ISSN (print) / ISBN 0304-4165
Quellenangaben Volume: 1790, Issue: 11, Pages: 1575-1585
Publishing Place Amsterdam
Reviewing status Peer reviewed