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Tregouet, D.A.* ; König, I.R.* ; Erdmann, J.* ; Munteanu, A.* ; Braund, P.S.* ; Hall, A.S.* ; Grosshennig, A.* ; Linsel-Nitschke, P.* ; Perret, C.* ; DeSuremain, M.* ; Meitinger, T. ; Wright, B.J.* ; Preuss, M.* ; Balmforth, A.J.* ; Ball, S.G* ; Meisinger, C. ; Germain, C.* ; Evans, A.* ; Arveiler, D.* ; Luc, G.* ; Ruidavets, J.B.* ; Morrison, C.* ; van der Harst, P.* ; Schreiber, S.* ; Neureuther, K.* ; Schäfer, A.* ; Bugert, P.* ; El Mokhtari, N.E.* ; Schrezenmeir, J.* ; Stark, K.* ; Rubin, D.* ; Wichmann, H.-E. ; Hengstenberg, C.* ; Ouwehand, W.* ; Ziegler, A.* ; Tiret, L.* ; Thompson, J.R.* ; Cambien, F.* ; Schunkert, H.* ; Samani, N.J.*

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

Nat. Genet. 41, 283-285 (2009)
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We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
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Publication type Article: Journal article
Document type Scientific Article
Keywords apolipoprotein(a) gene; myocardial-infarction; lipoprotein(a) levels; heart-disease; polymorphisms; ectim
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 41, Issue: 3, Pages: 283-285 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed