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Stemberger, C.* ; Neuenhahn, M.* ; Gebhardt, F.E.* ; Schiemann, M.* ; Buchholz, V.R.* ; Busch, D.H.

Stem cell-like plasticity of naïve and distinct memory CD8plusT cell subsets.

Semin. Immunol. 21, 62-68 (2009)
Open Access Green as soon as Postprint is submitted to ZB.
Most models regarding the 'clonal' origin of CD8(+) T cell effector and memory subset diversification suggest that during the first contact of a naive T cell with the priming antigen-presenting cell major decisions for subsequent differentiation are made. Data using novel single-cell T cell tracking technologies demonstrate that a single naive CD8(+) T cell can give rise to virtually all different subtypes of effector and memory T cells, and direct major determinants of subset diversification to the time period beyond the first cell division. Thereby, some 'stem cell-like' characteristics typical for naive T cells are probably still maintained within distinct subsets of memory T cells. These observations have direct consequences for clinical applications like adoptive T cell therapy.
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Publication type Article: Journal article
Document type Review
Keywords T cell memory differentiation; Single-cell transfer; Memory stem cell; Adoptive T cell transfer; mhc class-i; homeostatic proliferation; adoptive transfer; viral-infection; lymph-nodes; bone-marrow; selective expression; bacterial-infection; protective immunity; hematopoietic stem
ISSN (print) / ISBN 1044-5323
e-ISSN 1044-5323
Quellenangaben Volume: 21, Issue: 2, Pages: 62-68 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed