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Ascherl, G.* ; Hohenadl, C. ; Monini, P.* ; Zietz, C.* ; Browning, P.J.* ; Ensoli, B.* ; Stürzl, M.

Expression of human herpesvirus-8 (HHV-8) encoded pathogenic genes in kaposi's sarcoma ( KS) primary lesions.

Adv. Enzyme Regul. 39, 331-339 (1999)
Verlagsversion DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Transcription of six different HHV-8 specific mRNAs was examined in early- and late-stage KS primary lesions. Expression of the latency-associated T0.7 mRNA and of VP23 mRNA which is a specific marker of lytic/productive infection suggested that HHV-8 is secondarily recruited into the KS lesions by productively infected monocytes, macrophages. From these cells HHV-8 is transmitted to the KS spindle cells, which are latently infected. v-BCL-2, v-MCP-1 and v-IL-6 were not expressed in latently infected KS spindle cells, therefore the impact of these factors in KS pathogenesis appears to be low. By contrast, v-Cyclin D was highly expressed in almost all latently infected spindle cells and may therefore be an important factor triggering progression of late-stage KS lesions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0065-2571
e-ISSN 1873-2437
Quellenangaben Band: 39, Heft: 1, Seiten: 331-339 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed