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Corradi, A.* ; Croci, L.* ; Broccoli, V.* ; Zecchini, S.* ; Previtali, S.* ; Wurst, W. ; Amadio, S.* ; Maggi, R.* ; Quattrini, A.* ; Consalez, G.G.*

Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.

Development 130, 401-410 (2003)
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Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the EbJ2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism. In addition, Ebf2(-/-) peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Olf/Ebf genes; Neurogenesis; Neural development; Neuronal migration; Neuroendocrine; GnRH neurons; Peripheral nerve; Peripheral neuropathy; Dysmyelination; Gene targeting; COE2; O/E3
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Quellenangaben Band: 130, Heft: 2, Seiten: 401-410 Artikelnummer: , Supplement: ,
Verlag Company of Biologists
Begutachtungsstatus Peer reviewed