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Dietary intake of vitamin D and calcium and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Nutr. Cancer 65, 178-187 (2013)
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Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre- and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.871.32) and 1.02 (0.901.16) for pre- and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.801.19) and 0.90 (0.791.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre- and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter French E3n Cohort ; Dairy-products ; Sunlight Exposure ; Adolescent Diet ; Women ; Micronutrients ; Calibration ; Metaanalysis ; Prevention
ISSN (print) / ISBN 0163-5581
Zeitschrift Nutrition and Cancer
Quellenangaben Band: 65, Heft: 2, Seiten: 178-187
Verlag Routledge, Taylor & Francis Group
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology I (EPI1)