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Goller, T.* ; Seibold, U.K.* ; Kremmer, E. ; Voos, W.* ; Kolanus, W.*

Atad3 function is essential for early post-implantation development in the mouse.

PLoS ONE 8:e54799 (2013)
Verlagsversion Volltext DOI
Open Access Gold
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The mitochondrial AAA+-ATPase ATAD3 is implicated in the regulation of mitochondrial and ER dynamics and was shown to be necessary for larval development in Caenorhabditis elegans. In order to elucidate the relevance of ATAD3 for mammalian development, the phenotype of an Atad3 deficient mouse line was analyzed. Atad3 deficient embryos die around embryonic day E7.5 due to growth retardation and a defective development of the trophoblast lineage immediately after implantation into the uterus. This indicates an essential function of Atad3 for the progression of the first steps of post-implantation development at a time point when mitochondrial biogenesis and ATP production by oxidative phosphorylation are required. Therefore, murine Atad3 plays an important role in the biogenesis of mitochondria in trophoblast stem cells and in differentiating trophoblasts. At the biochemical level, we report here that ATAD3 is present in five native mitochondrial protein complexes of different sizes, indicating complex roles of the protein in mitochondrial architecture and function.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Embryonic Stem-cells ; M-aaa Protease ; Mitochondrial Fusion ; Mammalian-cells ; Molecular Characterization ; Cristae Morphogenesis ; Endoplasmic-reticulum ; Antioxidant Enzymes ; Cancer-cells ; C-elegans
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 8, Heft: 1, Seiten: , Artikelnummer: e54799 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed