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Jentsch, I.* ; Adler, I.-D. ; Carter, N.P.* ; Speicher, M.R.*

Karyotyping mouse chromosomes by multiplex-FISH (M-FISH).

Chromosome Res. 9, 211-214 (2001)
Verlagsversion Volltext DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Karyotyping of mouse chromosomes is a skillful art, which is laborious work even for experienced cytogeneticists. With the growing number of mouse models for human diseases, there is an increasing demand for automated mouse karyotyping systems. Here, such a karyotyping system for mouse chromosomes based on the multiplex-fluorescence in-situ hybridization (M-FISH) technology is shown. The system was tested on a number of individual mice with numerical and structural aberrations and its reproducibility and robustness verified. Mouse M-FISH should be a valuable tool for the analysis of chromosomal rearrangements in mice.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter fluorescence in situ hybridization (FISH); karyotyping; mouse chromosomes; multiplex-FISH (M-FISH); translocations; MULTICOLOR; TRANSLOCATIONS; HYBRIDIZATION; ABERRATIONS; MICE
ISSN (print) / ISBN 0967-3849
e-ISSN 1573-6849
Zeitschrift Chromosome Research
Quellenangaben Band: 9, Heft: 3, Seiten: 211-214 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed