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Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators.
Bioorg. Med. Chem. Lett. 20, 2920-2923 (2010)
In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor gamma, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Nuclear receptors; PPARγ; Truxillic acid derivatives; Reporter gene assay; Molecular docking; Structure-activity relationships