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Baarsma, H.A. ; Königshoff, M. ; Gosens, R.*

The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets.

Pharmacol. Ther. 138, 66-83 (2013)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Wingless/integrase-1 (WNT) signaling is a key pathway regulating various aspects of embryonic development; however it also underlies several pathological conditions in man, including various cancers and fibroproliferative diseases in several organs. Investigating the molecular processes involved in (canonical) WNT signaling will open new avenues for generating new therapeutics to specifically target diseases in which WNT signaling is aberrantly regulated. Here we describe the complexity of WNT signal transduction starting from the processes involved in WNT ligand biogenesis and secretion by WNT producing cells followed by a comprehensive overview of the molecular signaling events ultimately resulting in enhanced transcription of specific genes in WNT receiving cells. Finally, the possible targets for therapeutic intervention and the available pharmacological inhibitors for this complex signaling pathway are discussed.
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Publication type Article: Journal article
Document type Review
Keywords Beta-catenin ; Frizzled (fzd) ; Lipoprotein Receptor Related Proteins (lrp) ; Axin ; Casein Kinase (ck) ; Dishevelled (dvl); Glycogen-synthase Kinase-3 ; Frizzled-related Protein-1 ; Idiopathic Pulmonary-fibrosis ; Catenin Destruction Complex ; Receptor-related Protein-5 ; Cysteine-rich Domain ; Apc Tumor-suppressor ; Human Colon-cancer ; Beta-catenin ; Nuclear-localization
ISSN (print) / ISBN 0163-7258
e-ISSN 1879-016X
Quellenangaben Volume: 138, Issue: 1, Pages: 66-83 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) German Center for Lung Research (DZL)
Comprehensive Pneumology Center (CPC)