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Brakebusch, C.* ; Fillatreau, S.* ; Potocnik, A.J.* ; Bungartz, G.* ; Wilhelm, P.* ; Svensson, M.* ; Kearney, P.* ; Körner, H.* ; Gray, D.* ; Fässler, R.*

Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

Immunity 16, 465-477 (2002)
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Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 1074-7613
e-ISSN 1097-4180
Zeitschrift Immunity
Quellenangaben Band: 16, Heft: 3, Seiten: 465-477 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed