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Muehlberger, N. ; Jelinek, T.* ; Schlipkoeter, U.* ; von Sonnenburg, F.* ; Nothdurft, H.D.*

Effectiveness of chemoprophylaxis and other determinants of malaria in travellers to Kenya.

Trop. Med. Int. Health 3, 357-363 (1998)
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OBJECTIVE: To investigate the effectiveness of chemoprophylaxis and the determinants of malaria importation from Kenya. METHOD: In a population-based case-control study, 51 travellers from Bavaria diagnosed with falciparum malaria imported from Kenya (cases) and a sample of 383 healthy Bavarian travellers returning from Kenya (controls) were interviewed. Data were analysed by multiple logistic regression. RESULTS: Mefloquine (OR = 0.055; 95% CI 0.019-0.16) and chloroquine combined with proguanil (OR = 0.128; 95% CI 0.039-0.419) were highly protective against P. falciparum malaria, whereas other drugs were ineffective (OR = 1.225; 95% CI 0.536-2.803). Ineffective prophylaxis (10.4%) and non-prophylaxis (11.2%) were the main reasons for malaria importation. Travelling alone or with friends, male sex, and travel duration over 4 weeks could be identified as additional risk factors. The main reason for inadequate chemoprophylaxis was inappropriate medical advice (87.5%). Prophylaxis refusal occurred frequently despite correct advice (58.1%). Diagnosis was often delayed unnecessarily (27.5%). CONCLUSION: Malaria importation from Kenya could be reduced substantially (34%) by eliminating inappropriate medical advice.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter malaria chemoprophylaxis; imported malaria; Plasmodium falciparum; malaria prevention
ISSN (print) / ISBN 1360-2276
e-ISSN 1365-3156
Zeitschrift Tropical Medicine and International Health
Quellenangaben Band: 3, Heft: 5, Seiten: 357-363 Artikelnummer: , Supplement: ,
Verlag Wiley