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Zebrafish and steroids: What do we know and what do we need to know?

J. Steroid Biochem. Mol. Biol. 137, 165-173 (2013)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Zebrafish, Danio rerio, has long been used as a model organism in developmental biology. Nowadays, due to their advantages compared to other model animals, the fish gain popularity and are also increasingly used in endocrinology. This review focuses on an important aspect of endocrinology in zebrafish by summarizing the progress in steroid hormone related research. We present the state of the art of research on steroidogenesis, the action of steroid hormones, and steroid catabolism and cover the incremental usage of zebrafish as a test animal in endocrine disruption research. By this approach, we demonstrate that some aspects of steroid hormone research are well characterized (e.g., expression patterns of the genes involved), while other aspects such as functional analyses of enzymes, steroid hormone elimination, or the impact of steroid hormones on embryonic development or sex differentiation have not been extensively studied and are poorly understood.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Steroidogenesis ; Nuclear Receptor ; Endocrine Disruption ; Metabolism; Hormone-binding Globulin ; Fish Danio-rerio ; Gene-expression ; Rainbow-trout ; Cytosolic Sulfotransferases ; Glucocorticoid-receptor ; Endocrine Disruption ; Oncorhynchus-mykiss ; Androgen-receptor ; Adult Zebrafish
ISSN (print) / ISBN 0960-0760
e-ISSN 0960-0760
Quellenangaben Band: 137, Heft: , Seiten: 165-173 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)