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Pujol-Martí, J.* ; Baudoin, J.P.* ; Faucherre, A.* ; Kawakami, K.* ; López-Schier, H.*

Progressive neurogenesis defines lateralis somatotopy.

Dev. Dyn. 239, 1919-1930 (2010)
Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0002-9106
e-ISSN 1097-0177
Quellenangaben Band: 239, Heft: 7, Seiten: 1919-1930 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed