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Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog.
Cell Stem Cell 12, 426-439 (2013)
As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these reactive astrocytes, or glia, can form self-renewing and multipotent neurospheres in vitro. In the present study, we demonstrate that it is only invasive injury, such as stab wounding or cerebral ischemia, and not noninvasive injury conditions, such as chronic amyloidosis or induced neuronal death, that can elicit this increase in plasticity. Furthermore, we find that Sonic hedgehog (SHH) is the signal that acts directly on the astrocytes and is necessary and sufficient to elicit the stem cell response both in vitro and in vivo. These findings provide a molecular basis for how cells with neural stem cell lineage emerge at sites of brain injury and imply that the high levels of SHH known to enter the brain from extraneural sources after invasive injury can trigger this response.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Neural Stem/progenitor Cells; Focal Cerebral-ischemia; In-vitro; Spinal-cord; Astrocyte Proliferation; Zebrafish Telencephalon; Subventricular Zone; Alzheimers-disease; Transgenic Mice; Self-renewal
ISSN (print) / ISBN 1934-5909
Zeitschrift Cell Stem Cell
Quellenangaben Band: 12, Heft: 4, Seiten: 426-439
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)