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Lee, H.S.* ; Briese, T.* ; Winkler, C. ; Rewers, M.* ; Bonifacio, E.* ; Hyoty, H.* ; Pflueger, M. ; Simell, O.* ; She, J.X.* ; Hagopian, W.* ; Lernmark, A.* ; Akolkar, B.* ; Krischer, J.P.* ; Ziegler, A.-G. ; TEDDY Study Group (*)

Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes.

Diabetologia 56, 1705-1711 (2013)
Verlagsversion Volltext DOI
AIMS/HYPOTHESIS: Viruses are candidate causative agents in the pathogenesis of autoimmune (type 1) diabetes. We hypothesised that children with a rapid onset of type 1 diabetes may have been exposed to such agents shortly before the initiation of islet autoimmunity, possibly at high dose, and thus study of these children could help identify viruses involved in the development of autoimmune diabetes. METHODS: We used next-generation sequencing to search for viruses in plasma samples and examined the history of infection and fever in children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study who progressed to type 1 diabetes within 6 months from the appearance of islet autoimmunity, and in matched islet-autoantibody-negative controls. RESULTS: Viruses were not detected more frequently in plasma from rapid-onset patients than in controls during the period surrounding seroconversion. In addition, infection histories were found to be similar between children with rapid-onset diabetes and control children, although episodes of fever were reported less frequently in children with rapid-onset diabetes. CONCLUSIONS/INTERPRETATION: These findings do not support the presence of viraemia around the time of seroconversion in young children with rapid-onset type 1 diabetes.  
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter GB virus C; Human herpes virus 6; Human rhinnovirus C; Infections; Islet autoimmunity; Next-generation deep sequencing; Parvovirus B19; TEDDY study; Type 1 diabetes mellitus; No Evidence ; Infection ; Identification ; Pathogenesis ; Mellitus ; Diseases ; Risk
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Zeitschrift Diabetologia
Quellenangaben Band: 56, Heft: 8, Seiten: 1705-1711 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research Type 1 (IDF)
Institute for Pancreatic Beta Cell Research (IPI)