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Schneider, F.* ; Hoster, E.* ; Unterhalt, M.* ; Schneider, S.* ; Dufour, A.* ; Benthaus, T.* ; Mellert, G.* ; Zellmeier, E.* ; Bohlander, S.K. ; Feuring-Buske, M. ; Buske, C. ; Braess, J.* ; Fritsch, S.* ; Heinecke, A.* ; Sauerland, M.C.* ; Berdel, W.E.* ; Buechner, T.* ; Woermann, B.J.* ; Hiddemann, W. ; Spiekermann, K.

NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).

Blood 113, 5250-5253 (2009)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mutations in the NPM1 gene represent the most frequent genetic alterations in patients with acute myeloid leukemia (AML) and are associated with a favorable outcome. In 690 normal karyotype (NK) AML patients the complete remission rates (CRs) and the percentage of patients with adequate in vivo blast cell reduction 1 week after the end of the first induction cycle were significantly higher in NPM1(+) (75% and 80%, respectively) than in NPM1(-) (57% and 57%, respectively) patients, but were unaffected by the FLT3-ITD status. Multivariate analyses revealed the presence of a NPM1 mutation as an independent positive prognostic factor for the achievement of an adequate day-16 blast clearance and a CR. In conclusion, NPM1(+) blast cells show a high in vivo sensitivity toward induction chemotherapy irrespective of the FLT3-ITD mutation status. These findings provide insight into the pathophysiology and help to understand the favorable clinical outcome of patients with NPM1(+) AML.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter acute myeloid-leukemia; acute myelogenous leukemia; younger adults; prognostic relevance; favorable prognosis; normal cytogenetics; nucleophosmin npm1; induction therapy; gene-mutations; kappa-b
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Zeitschrift Blood
Quellenangaben Band: 113, Heft: 21, Seiten: 5250-5253 Artikelnummer: , Supplement: ,
Verlag American Society of Hematology
Begutachtungsstatus Peer reviewed