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Profile likelihood in systems biology.

FEBS J. 280, 2564-2571 (2013)
Open Access Green as soon as Postprint is submitted to ZB.
Inferring knowledge about biological processes by a mathematical description is a major characteristic of Systems Biology. To understand and predict system's behavior the available experimental information is translated into a mathematical model. Since the availability of experimental data is often limited and measurements contain noise, it is essential to appropriately translate experimental uncertainty to model parameters as well as to model predictions. This is especially important in Systems Biology because typically large and complex models are applied and therefore the limited experimental knowledge might yield weakly specified model components. Likelihood profiles have been recently suggested and applied in the Systems Biology for assessing parameter and prediction uncertainty. In this article, the profile likelihood concept is reviewed and the potential of the approach is demonstrated for a model of the erythropoietin (EPO) receptor.
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Publication type Article: Journal article
Document type Review
Keywords Parameter Estimation ; Prediction ; Profile Likelihood ; Propagation Of Errors ; Uncertainty; Identifiability Analysis ; Predictions ; Reveals ; Models ; Range
Reviewing status