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Caesium accumulation in yeast and plants is selectively repressed by loss of the SNARE Sec22p/SEC22.

Nat. Commun. 4:2092 (2013)
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Open Access Gold
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The non-essential cation caesium (Cs+) is assimilated by all organisms. Thus, anthropogenically released radiocaesium is of concern to agriculture. Cs+ accumulates owing to its chemical similarity to the potassium ion (K+). The apparent lack of a Cs+-specific uptake mechanism has obstructed attempts to manipulate Cs+ accumulation without causing pleiotropic effects. Here we show that the SNARE protein Sec22p/SEC22 specifically impacts Cs+ accumulation in yeast and in plants. Loss of Saccharomyces cerevisiae Sec22p does not affect K+ homeostasis, yet halves Cs+ concentration compared with the wild type. Mathematical modelling of the uptake time course predicts a compromised vacuolar Cs+ deposition in sec22Δ. Biochemical fractionation confirms this and indicates a new feature of Sec22p in enhancing non-selective cation deposition. A developmentally controlled loss-of-function mutant of the orthologous Arabidopsis thaliana SEC22 phenocopies the reduced Cs+ uptake without affecting plant growth. This finding provides a new strategy to reduce radiocaesium entry into the food chain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Plasma-membrane Atpase ; Saccharomyces-cerevisiae ; Arabidopsis-thaliana ; Vacuolar Membrane ; Strontium Accumulation ; Alpha-mannosidase ; Escherichia-coli ; K+ Uptake ; V-atpase ; Transport
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 4, Heft: , Seiten: , Artikelnummer: 2092 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus