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Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Nat. Genet. 41, 879-81 (2009)
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
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Publication type Article: Journal article
Document type Scientific Article
Keywords transcription factor atbf1; lifetime risk; differentiation; prevalence