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Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.

Genesis 46, 530-536 (2008)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Taking advantage of a mutant estrogen receptor ligand binding domain (ER(T2)), we developed novel Caspase fusion proteins for inducible apoptosis. We show that Caspase-ER(T2) fusion proteins become specifically activated by the synthetic ligand 4-OH- tamoxifen and rapidly induce apoptotic cell death in human, murine, and zebrafish cells. This novel tool for targeted cell ablation greatly facilitates the generation of disease models as well as developmental and regeneration studies in model organisms.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter caspase; apoptosis; tamoxifen; cell ablation; estrogen receptor
ISSN (print) / ISBN 1526-954X
e-ISSN 1526-968X
Quellenangaben Band: 46, Heft: 10, Seiten: 530-536 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed