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Compression of Born ratio for fluorescence molecular tomography/X-ray computed tomography hybrid imaging: Methodology and in vivo validation.

Opt. Lett. 38, 2324-2326 (2013)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The 360° rotation geometry of the hybrid fluorescence molecular tomography/x-ray computed tomography modality allows for acquisition of very large datasets, which pose numerical limitations on the reconstruction. We propose a compression method that takes advantage of the correlation of the Born-normalized signal among sources in spatially formed clusters to reduce the size of system model. The proposed method has been validated using an ex vivo study and an in vivo study of a nude mouse with a subcutaneous 4T1 tumor, with and without inclusion of a priori anatomical information. Compression rates of up to two orders of magnitude with minimum distortion of reconstruction have been demonstrated, resulting in large reduction in weight matrix size and reconstruction time.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diffuse Optical Tomography ; System ; Space
ISSN (print) / ISBN 0146-9592
e-ISSN 1539-4794
Zeitschrift Optics Letters
Quellenangaben Band: 38, Heft: 13, Seiten: 2324-2326 Artikelnummer: , Supplement: ,
Verlag Optical Society of America (OSA)
Begutachtungsstatus Peer reviewed