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Compression of Born ratio for fluorescence molecular tomography/X-ray computed tomography hybrid imaging: Methodology and in vivo validation.
Opt. Lett. 38, 2324-2326 (2013)
The 360° rotation geometry of the hybrid fluorescence molecular tomography/x-ray computed tomography modality allows for acquisition of very large datasets, which pose numerical limitations on the reconstruction. We propose a compression method that takes advantage of the correlation of the Born-normalized signal among sources in spatially formed clusters to reduce the size of system model. The proposed method has been validated using an ex vivo study and an in vivo study of a nude mouse with a subcutaneous 4T1 tumor, with and without inclusion of a priori anatomical information. Compression rates of up to two orders of magnitude with minimum distortion of reconstruction have been demonstrated, resulting in large reduction in weight matrix size and reconstruction time.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Diffuse Optical Tomography ; System ; Space
ISSN (print) / ISBN 0146-9592
Journal Optics Letters
Quellenangaben Volume: 38, Issue: 13, Pages: 2324-2326
Publisher Optical Society of America (OSA)
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)