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Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels.

Histochem. Cell Biol. 140, 93-104 (2013)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and quantitative distribution maps of small pharmaceutical-active molecules and their metabolites in tissue sections in situ. The simplicity, high sensitivity and ability to provide comprehensive spatial distribution maps of different classes of biomolecules make MSI a valuable tool to complement histopathology for diagnostics and biomarker discovery. In this review, qualitative and quantitative MSI of drugs and metabolites in tissue at therapeutic levels are discussed and the impact of this technique in drug discovery and clinical research is highlighted.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Mass Spectrometry Imaging; Quantitation; Drug; Metabolite; In Situ; High Resolution; Direct Molecular Analysis ; Rat-brain Tissue ; Maldi-ms ; High-resolution ; Ion-trap ; Matrix ; Sections ; Localization ; Normalization ; Distributions
ISSN (print) / ISBN 0948-6143
e-ISSN 1432-119X
Zeitschrift Histochemistry and Cell Biology
Quellenangaben Band: 140, Heft: 2, Seiten: 93-104 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus