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Current frontiers in clinical research application of MALDI imaging mass spectrometry.

Expert Rev. Proteomics 10, 259-273 (2013)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Imaging mass spectrometry (IMS) is still a relatively young imaging technique that allows molecular mapping of diverse biomolecules in their natural environment. Furthermore, IMS allows for the direct correlation of tissue histology and proteomic, metabolomic or lipidomic information. In recent years, increasing efforts have been made in the development and improvement of IMS, which aid its application in clinical research. In this article, current frontiers of clinical research applications of IMS are discussed in the context of recent developments of IMS technology. Critical stages in planning and realizing clinical studies are highlighted. Finally, a selection of recent prominent examples for successful clinical applications of IMS is presented.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Clinical Proteomics ; Imaging Mass Spectrometry ; Maldi Imaging Mass Spectrometry ; Molecular Pathology ; Tissue Protein Analysis; Paraffin-embedded Tissue ; Matrix Application Method ; In-source Decay ; Breast-cancer ; Biomarker Discovery ; Protein Expression ; Drug Distribution ; Gastric-cancer ; Mouse-brain ; Intratumor Heterogeneity
ISSN (print) / ISBN 1478-9450
e-ISSN 1744-8387
Quellenangaben Band: 10, Heft: 3, Seiten: 259-273 Artikelnummer: , Supplement: ,
Verlag Expert Reviews
Begutachtungsstatus Peer reviewed