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Iterative self-organizing atherosclerotic tissue labeling in intravascular ultrasound images and comparison with virtual histology.
IEEE Trans. Bio. Med. Eng. 59, 3039-3049 (2012)
Verlagsversion Volltext DOI
Intravascular ultrasound (IVUS) is the predominant imaging modality in the field of interventional cardiology that provides real-time cross-sectional images of coronary arteries and the extent of atherosclerosis. Due to heterogeneity of lesions and stringent spatial/spectral behavior of tissues, atherosclerotic plaque characterization has always been a challenge and still is an open problem. In this paper, we present a systematic framework from in vitro data collection, histology preparation, IVUS-histology registration along with matching procedure, and finally a robust texture-derived unsupervised atherosclerotic plaque labeling. We have performed our algorithm on in vitro and in vivo images acquired with single-element 40 MHz and 64-elements phased array 20 MHz transducers, respectively. In former case, we have quantified results by local contrasting of constructed tissue colormaps with corresponding histology images employing an independent expert and in the latter case, virtual histology images have been utilized for comparison. We tackle one of the main challenges in the field that is the reliability of tissues behind arc of calcified plaques and validate the results through a novel random walks framework by incorporating underlying physics of ultrasound imaging. We conclude that proposed framework is a formidable approach for retrieving imperative information regarding tissues and building a reliable training dataset for supervised classification and its extension for in vivo applications.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Atherosclerosis ; Histology ; Intravascular Ultrasound (ivus) ; Plaque Characterization ; Random Walks ; Wavelet Packets
ISSN (print) / ISBN 0018-9294
Zeitschrift IEEE Transactions on Bio-Medical Electronics
Quellenangaben Band: 59, Heft: 11, Seiten: 3039-3049
Verlag Institute of Electrical and Electronics Engineers (IEEE)
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)