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Functional ribosome biogenesis is a prerequisite for p53 destabilization: Impact of chemotherapy on nucleolar functions and RNA metabolism.

Biol. Chem. 394, 1133-1143 (2013)
Publ. Version/Full Text Volltext DOI
Open Access Green as soon as Postprint is submitted to ZB.
The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as a highly sensitive sensor of cellular stress and an important regulator of the tumor suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signaling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilize p53 by inhibiting nucleolar functions.
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Publication type Article: Journal article
Document type Review
Keywords Chemotherapy ; Kinase Inhibitor ; Ribosome Biogenesis ; Rrna Processing ; Tumor Suppressor P53; Chronic Lymphocytic-leukemia ; Polymerase-i-transcription ; Cyclin-dependent Kinases ; Human Cancer-cells ; Wild-type P53 ; Protein-synthesis ; Dna-damage ; Cytoplasmic Maturation ; Nuclear Accumulation ; Carcinoma Cells
ISSN (print) / ISBN 1431-6730
e-ISSN 1437-4315
Quellenangaben Volume: 394, Issue: 9, Pages: 1133-1143 Article Number: , Supplement: ,
Publisher de Gruyter
Reviewing status Peer reviewed