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Luczynska, A.* ; Kaaks, R.* ; Rohrmann, S.* ; Becker, S.* ; Linseisen, J. ; Buijsse, B.* ; Overvad, K.* ; Trichopoulou, A.* ; Valanou, E.* ; Barmpitsioti, A.* ; Masala, G.* ; Agnoli, C.* ; Tumino, R.* ; Panico, S.* ; Bueno-de-Mesquita, H.B.* ; van Duijnhoven, F.J.* ; Peeters, P.H.M.* ; Vernieulen, R.* ; Weiderpass, E.* ; Brustad, M.* ; Skeie, G.* ; González, C.A.* ; Jakszyn, P.* ; Quirós, J.R.* ; Sánchez, M.J.* ; Huerta, J.M.* ; Ardanaz, E.* ; Melin, B.* ; Johansson, A.S.* ; Almquist, M.* ; Maim, J.* ; Khaw, K.T.* ; Wareham, N.J.* ; Travis, R.C.* ; Fedirko, V.* ; Romieu, I.* ; Jenab, M.* ; Gallo, V.* ; Riboli, E.* ; Vineis, P.* ; Nieters, A.*

Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the European Prospective Investigation into Cancer and Nutrition.

Am. J. Clin. Nutr. 98, 827-838 (2013)
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Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >= 2y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Non-hodgkin-lymphoma ; Chronic Lymphocytic-leukemia ; Vitamin-d Status ; Sun Exposure ; Ultraviolet-radiation ; Subsequent Risk ; Infections ; Disease ; Supplementation ; Association
ISSN (print) / ISBN 0002-9165
e-ISSN 1938-3207
Quellenangaben Volume: 98, Issue: 3, Pages: 827-838 Article Number: , Supplement: ,
Publisher American Society for Nutrition
Reviewing status Peer reviewed