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Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels.

Transcription 4, 192-197 (2013)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The proto-oncogene c-myc encodes a basic helix-loop-helix leucine zipper transcription factor (c-Myc). c-Myc plays a crucial role in cell growth and proliferation. Here, we examined how expression of c-Myc target genes and cell proliferation depend on variation of c-Myc protein levels. We show that proliferation rates, the number of cells in S-phase, and cell size increased in a dose-dependent manner in response to increasing c-Myc levels. Likewise, the mRNA levels of c-Myc responsive genes steadily increased with rising c-Myc levels. Strikingly, steady-state mRNA levels of c-Myc target genes did not saturate even at highest c-Myc concentrations. These characteristics predestine c-Myc levels as a cellular rheostat for the control and fine-tuning of cell proliferation and growth rates.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Gene activity; Transcription factor; Titration; Transactivation
ISSN (print) / ISBN 2154-1264
e-ISSN 2154-1272
Journal Transcription
Quellenangaben Volume: 4, Issue: 4, Pages: 192-197 Article Number: , Supplement: ,
Publisher Landes Bioscience
Reviewing status Peer reviewed