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Long-term experiment to study the development, interaction and influencing factors of DEXA parameters.

Mamm. Genome 24, 376-388 (2013)
Postprint DOI
Open Access Green
Dual-energy X-ray absorption (DEXA) is commonly used to measure bone mineral density (BMD), bone mineral content (BMC), and body composition data (fat mass and lean mass) for phenotype assessment in mice. We were interested in the long-term development of BMD, BMC, lean mass, and fat mass of mice, also taking into account sex and genetic background. The dataset was used to analyze correlations among the different parameters. We analyzed males and females from inbred strains C3HeB/FeJ and C57BL/6J, starting from 42 until 528 days of age. To evaluate the effect of husbandry systems, we repeated a part of the study in a second facility with a different caging system. We also assessed different DEXA settings and repeatability of the scans. The results of this study were used to draw conclusions for the use of DEXA analysis in mouse phenotyping approaches.
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Publication type Article: Journal article
Document type Scientific Article
Keywords X-ray Absorptiometry ; Future Perspectives ; Body-composition ; Bone-density ; Genome-wide ; Mice ; Mouse ; Mutagenesis
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Quellenangaben Volume: 24, Issue: 9-10, Pages: 376-388 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed