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Koch, W.* ; Hoppmann, P.* ; Michou, E.* ; Jung, V.* ; Pfeufer, A. ; Mueller, J.C.* ; Gieger, C. ; Wichmann, H.-E. ; Meitinger, T. ; Schömig, A.* ; Kastrati, A.*

Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.

Hum. Mol. Genet. 16, 1821-1827 (2007)
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Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13.1), encoding a regulator for lymphotoxin-alpha, the product of the LTA gene, have been reported to be linked with the risk of myocardial infarction in Japanese. We employed nine polymorphisms from the BAT1-NFKBIL1-LTA region and one polymorphism from the LGALS2 gene, and investigated whether such associations were also present in Europeans. The study included 3657 patients with myocardial infarction and 1211 control individuals with angiographically normal coronary arteries. Minor homozygous genotypes of polymorphisms in BAT1 (rs2239527, -23C/G), NFKBIL1 (rs2071592, -63T/A) and LTA (rs1800683, -162G/A; rs909253, 252G/A; rs1041981, Thr26Asn) were associated with moderately protective effects against myocardial infarction (P
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Publication type Article: Journal article
Document type Scientific Article
Keywords LYMPHOTOXIN-ALPHA GENE; SINGLE-NUCLEOTIDE POLYMORPHISMS; HISTOCOMPATIBILITY COMPLEX; SUSCEPTIBILITY LOCUS; HAPLOTYPE; DISEASE; ATHEROSCLEROSIS; PROMOTER; POPULATION; JAPANESE
ISSN (print) / ISBN 0964-6906
e-ISSN 1460-2083
Quellenangaben Volume: 16, Issue: 15, Pages: 1821-1827 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed