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Claessen, H.* ; Strassburger, K.* ; Tepel, M.* ; Waldeyer, R.* ; Chernyak, N.* ; Jülich, F.* ; Albers, B.* ; Bächle, C.* ; Rathmann, W.* ; Meisinger, C. ; Thorand, B. ; Hunger, M. ; Schunk, M. ; Stark, R. ; Rückert, I.-M. ; Peters, A. ; Huth, C. ; Stöckl, D. ; Giani, G.* ; Holle, R. ; Icks, A.*

Medication costs by glucose tolerance stage in younger and older women and men: Results from the population-based KORA survey in Germany.

Exp. Clin. Endocrinol. Diabet. 121, 614-623 (2013)
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To estimate medication costs in individuals with diagnosed diabetes, undetected diabetes, impaired glucose regulation and normal blood glucose values in a population-based sample by age and sex.Using the KORA F4 follow-up survey, conducted in 2006-2008 (n=2611, age 40-82 years), we identified individuals' glucose tolerance status by means of an oral glucose tolerance test. We assessed all medications taken regularly, calculated age-sex specific medication costs and estimated cost ratios for total, total without antihyperglycemic drugs, and cardiovascular medication, using multiple 2-part regression models.Compared to individuals with normal glucose values, costs were increased in known diabetes, undetected diabetes and impaired glucose regulation, which was more pronounced in participants aged 40-59 years than in those aged 60-82 years (cost ratios for all medications: 40-59 years: 2.85; 95%-confidence interval: 1.78-4.54, 2.00; 1.22-3.29 and 1.53; 1.12-2.09; 60-82 years: 2.04; 1.71-2.43, 1.17; 0.90-1.51 and 1.09; 0.94-1.28). Compared to individuals with diagnosed diabetes, costs were significantly lower among individuals with impaired glucose regulation across all age and sex strata, also when antihyperglycemic medication was excluded (40-59 years: 0.60; 0.36-0.98, 60-82 years: 0.74; 0.60-0.90; men: 0.72; 0.56-0.93; women: 0.72; 0.54-0.96).We could quantify age- and sex-specific medication costs and cost ratios in individuals with diagnosed diabetes, undetected diabetes and impaired glucose regulation compared to those with normal glucose values, using data of a population-based sample, with oral glucose tolerance test-based identification of diabetes states. These results may help to validly estimate cost-effectiveness of screening and early treatment or prevention of diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Drug Costs ; Glucose Tolerance Status ; Age-sex-strata ; Population-based Survey; Prescription Drug Costs ; Diabetes-mellitus ; Care Costs ; Southern Germany ; Type-2 ; Diagnosis ; Outcomes ; Cohort ; Risk ; Interventions
ISSN (print) / ISBN 0947-7349
e-ISSN 1439-3646
Quellenangaben Volume: 121, Issue: 10, Pages: 614-623 Article Number: , Supplement: ,
Publisher Thieme
Publishing Place Stuttgart
Reviewing status Peer reviewed