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Effect of nitric oxide on gene transcription - S-nitrosylation of nuclear proteins.

Front. Plant Sci. 4:293 (2013)
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Open Access Gold
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Nitric oxide (NO) plays an important role in many different physiological processes in plants. It mainly acts by post-translationally modifying proteins. Modification of cysteine residues termed as S-nitrosylation is believed to be the most important mechanism for transduction of bioactivity of NO. The first proteins found to be nitrosylated were mainly of cytoplasmic origin or isolated from mitochondria and peroxisomes. Interestingly, it was shown that redox-sensitive transcription factors are also nitrosylated and that NO influences the redox-dependent nuclear transport of some proteins. This implies that NO plays a role in regulating transcription and/or general nuclear metabolism which is a fascinating new aspect of NO signaling in plants. In this review, we will discuss the impact of S-nitrosylation on nuclear plant proteins with a focus on transcriptional regulation, describe the function of this modification and draw also comparisons to the animal system in which S-nitrosylation of nuclear proteins is a well characterized concept.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Protein S-nitrosylation; Nitric oxide; Post-translational modification; Nuclear proteins; Redox-modification; Cytosolic Glyceraldehyde-3-phosphate Dehydrogenase; Plant-disease Resistance; Ii Histone Deacetylases; Dna-binding Activity; Nf-kappa-b; Arabidopsis-thaliana; Salicylic-acid; Cell-death; Signaling Pathway; Redox Regulation
ISSN (print) / ISBN 1664-462X
e-ISSN 1664-462X
Quellenangaben Volume: 4, Issue: , Pages: , Article Number: 293 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Reviewing status Peer reviewed